Bioassay-guided isolation of the antimicrobial compounds of Coleus amboinicus Loureiro (Lamiaceae)

Authors

  • E.A. Vasquez Philippine Root Crop Research and Training Center, Leyte State University, Baybay, Leyte, Philippines
  • W. Kraus Institut fur Chemie, Institut fur Phytomedizin, Universitat Hohenheim, 70593 Stuttgart Germany
  • J. Conrad 'Institut fur Chemie, Institut fur Phytomedizin, Universitat Hohenheim, 70593 Stuttgart Germany
  • B. Volger 'Institut fur Chemie, Institut fur Phytomedizin, Universitat Hohenheim, 70593 Stuttgart Germany
  • C. Zebitz Department of Entomology, University of the Philippines Los Baños, Laguna, Philippines
  • B.M. Rejesus and Department of Entomology, University of the Philippines Los Baños, Laguna, Philippines

Keywords:

Coleus amboinicus, essential oil, antibacterial, antifungal, carvacrol, caryophyllene_4, 5-oxide

Abstract

The essential oil of the aerial part of Coleus amboinicus showed antibacterial activity against Bacillus subtilis (gram +) and Pseudomonas fluorescens (gram -) and antifungal activity against Cladosporium cucumerinum. Bioassay-guided fractionation revealed that carvacrol and ß-caryophyllene-4,5-oxide were the major contributors to the antimicrobial activity of the essential oil. The sesquiterpene α-humulene and monoterpenes α-pinene, α-terpmene and cymene present in significant amounts were inactive.

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Submitted

2024-12-05

Published

2004-11-20

How to Cite

Vasquez, E., Kraus, W., Conrad, J., Volger, B., Zebitz, C., & Rejesus, B. (2004). Bioassay-guided isolation of the antimicrobial compounds of Coleus amboinicus Loureiro (Lamiaceae). Annals of Tropical Research, 26(1&2), 167–183. Retrieved from https://atr.vsu.edu.ph/article/view/451

Issue

Vol. 26 No. 1&2 (2004)

Section

Research Article

License

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